2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aldose Reductase

Aldose Reductase

Aldose Reductase

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Aldose reductase is a small, cytosolic, monomeric enzyme which belongs to the aldo-keto reductase superfamily. Aldose reductase catalyzes the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of a wide variety of aromatic and aliphatic carbonyl compounds. It is implicated in the development of diabetic and galactosemic complications involving the lens, retina, nerves, and kidney.

Aldose reductase is both the key enzyme of the polyol pathway, whose activation under hyperglycemic conditions leads to the development of chronic diabetic complications, and the crucial promoter of inflammatory and cytotoxic conditions, even under a normoglycemic status. Aldose reductase represents an excellent drug target and a huge effort is being done to disclose novel compounds able to inhibit it.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-173453
    AKR1C3-IN-15
    		Inhibitor
    AKR1C3-IN-15 (compound 30) is a potent and selective AKR1C3 inhibitor with an IC50 of 5 nM. AKR1C3-IN-15 enhances Sorafenib (HY-10201)-induced ROS generation, promoted apoptosis, and restored sorafenib sensitivity in HCC models both in vitro and in vivo.
    AKR1C3-IN-15
  • HY-N12313
    Corybulbine
    		Inhibitor
    Corybulbine, an alkaloid isolated from the methanolic extract of Corydalis ternata, is an aldose reductase (ALR2) inhibitor. Corybulbine can be used for diabetic complications research.
    Corybulbine
  • HY-157810
    AKR1C3-IN-11
    		Inhibitor
    AKR1C3-IN-11 (Compound 6e) is a Aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 2.0 μM. AKR1C3-IN-11 inhibit cell proliferation in combination with abiraterone (HY-70013). AKR1C3-IN-11 can be used for the research of prostate cancer.
    AKR1C3-IN-11
  • HY-117339
    AD-5467
    		Inhibitor
    AD-5467 is a potent and selective aldose reductase inhibitor. AD-5467 exhibits antidiabetic effect. AD-5467 can be used for the research of metabolic disease, such as diabetes.
    AD-5467
  • HY-N0033R
    Poliumoside (Standard)
    		Inhibitor
    Poliumoside (Standard) is the analytical standard of Poliumoside. This product is intended for research and analytical applications. Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC50s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity.
    Poliumoside (Standard)
  • HY-N14447
    Salfredin A3
    		Inhibitor
    Salfredin A3 is an aldose reductase inhibitor.
    Salfredin A3
  • HY-N14186
    Asperaldin
    		Inhibitor
    Asperaldin is a potent aldose reductase (RLAR) inhibitor found in Aspergillus niger CFR-1046.
    Asperaldin
  • HY-N14431
    Salfredin C2
    		Inhibitor
    Salfredin C2 is an aldose reductase inhibitor.
    Salfredin C2
  • HY-N14451
    Salfredin C1
    		Inhibitor
    Salfredin C1 is an aldose reductase inhibitor.
    Salfredin C1
  • HY-50289R
    Sorbinil (Standard)
    		Inhibitor
    Sorbinil (Standard) is the analytical standard of Sorbinil. This product is intended for research and analytical applications. Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.
    Sorbinil (Standard)
  • HY-N4089R
    Quercetin 3-gentiobioside (Standard)
    		Inhibitor
    Quercetin 3-gentiobioside (Standard) is the analytical standard of Quercetin 3-gentiobioside (HY-N4089). This product is intended for research and analytical applications. Quercetin 3-gentiobioside is a flavonoid compound and aromatase inhibitor with a Ki of 46.77 nM. Quercetin 3-gentiobioside is also an inhibitor of aldose reductase (AR) and the formation of advanced glycation end products (AGEs), with IC50 values of 10.60 μM and 109.46 μM, respectively. Quercetin 3-gentiobioside can be used in the research of breast cancer, diabetes and its complications.
    Quercetin 3-gentiobioside (Standard)
  • HY-16500R
    Tolrestat (Standard)
    		Inhibitor
    Tolrestat (Standard) is the analytical standard of Tolrestat. This product is intended for research and analytical applications. Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM.
    Tolrestat (Standard)
  • HY-175862
    ALR2-IN-9
    		Inhibitor
    ALR2-IN-9 is a potent ALR2 inhibitor (IC50 = 21.8 nM) with excellent antioxidant activity (EC50 for DPPH radical scavenging = 2.8 μM). ALR2-IN-9 interacts directly with Reactive Oxygen Species (ROS)/Reactive Nitrogen Species (RNS) and interrupts the free radical chain reactions, and as an endogenous enzymatic antioxidant regulator, which regulates enzyme functions of CAT and SOD. ALR2-IN-9 regulates PI3K/Akt/Nrf2 pathway to attenuate hyperglycemia-mediated mitochondrial superoxide overproduction in vitro, and ameliorates CuSO4- and H2O2-induced oxidative stress in vivo. ALR2-IN-9 prolongs lifespan of C. elegans via the regulation of stress response genes such as PMK-1. ALR2-IN-9 is a promising anti-aging drug candidate. ALR2-IN-9 can be used for diabetic complication research.
    ALR2-IN-9
  • HY-N14419
    Salfredin C3
    		Inhibitor
    Salfredin C3 is an aldose reductase inhibitor.
    Salfredin C3
  • HY-N14449
    Salfredin A4
    		Inhibitor
    Salfredin A4 is an aldose reductase inhibitor.
    Salfredin A4
  • HY-N0309R
    Soyasaponin Ba (Standard)
    		Inhibitor
    Soyasaponin Ba (Standard) is the analytical standard of Soyasaponin Ba. This product is intended for research and analytical applications. Soyasaponin Ba is a soyasaponin isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitors (ARI).
    Soyasaponin Ba (Standard)
  • HY-16255R
    Imirestat (Standard)
    		Inhibitor
    Imirestat (Standard) is the analytical standard of Imirestat. This product is intended for research and analytical applications. Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.
    Imirestat (Standard)
  • HY-N12472
    Floramanoside C
    		Inhibitor
    Floramanoside C shows 2,2-diphenyl-1-picrylhydrazyl scavenging and aldose reductase inhibitory activities.
    Floramanoside C
  • HY-W319094
    4′-Hydroxyflavone
    		Inhibitor
    4′-Hydroxyflavone (compound 50) can inhibit aldose reductase, with IC50 12 μM.
    4′-Hydroxyflavone
  • HY-155164
    WF-3681
    		Inhibitor
    WF-3681 (compound 1) is an aldose reductase inhibitor and a fungal metabolite.
    WF-3681
Cat. No. Product Name / Synonyms Application Reactivity